Beclometasone dipropionate

  • 9 -chloro- 11β ,17,21 -trihydroxy- 16β - methylpregna -1 ,4-diene- 3 ,20-dione
  • Beclomethasone
  • Beclometasone
  • 4419-39-0
  • 5534-09-8 ( beclomethasone dipropionate)

A07EA07, D07AC15, R01AD01, R03BA01

  • Anti-inflammatory drug
  • Glucocorticoids

212 ° C ( dipropionate decomposition)

Risk

> 3750 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Beclomethasone is a synthetic glucocorticoid with anti-inflammatory and vasoconstrictive properties. It is used as a drug for the topical treatment of asthma, allergic rhinitis, and sinusitis. Is also used in the Dipropionsäureester ( beclomethasone -17 ,21- dipropionate, on package inserts often only beclomethasone dipropionate).

Pharmacokinetic properties

The drug beclomethasone -17 ,21- dipropionate has been used since 1972 as a prodrug. After hydrolysis by esterases to the active metabolite beclomethasone -17 - monopropionate arises. In the liver they are converted by means of first-pass effect in pharmacologically inactive metabolites such as beclomethasone -21- monopropionate and beclomethasone ( free alcohol ). This limits the systemic bioavailability, and toxicity.

Effect

Beclometasone has anti-inflammatory, immunosuppressive and anti-allergic. It is thus used for the treatment of asthmatic disease shapes, and difficulty breathing. The full effect occurs after a few hours or days.

Trade names

Aero corticosteroid (A), BECeco (CH), Beconase (D, CH), Bronchocort (D), cyclo Caps (D), Douglan (A), Janik (D), LivocabTM (D) Qvar (A, CH), RatioAllerg (D) Rhinivict (D), Sanasthmax (D), Sanasthmyl (D), Ventolair (D), Clenil spray (I ), numerous generics (D, A)

Formodual (A), Foster ( D, A), Inuvair (D)

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Dangerous Substances Directive (67/548/EEC) Active ingredient Digital Object Identifier
111683
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