Buspirone

8 - {4 - [4 - ( pyrimidin-2- yl) piperazin-1 -yl] butyl} -8 - azaspiro [4.5 ] decane - 7 ,9 -dione

• 36505-84-7
• 33386-08-2 (hydrochloride)

N05BE01

Anxiolytic

Selective serotonin agonist

Risk

Template: Infobox chemical / molecular formula search available

Buspirone is a drug which acts anxiolytic. Its advantage over benzodiazepines lies in the fact that he current state of the research, does not make you dependent. It also is non-sedative. The effect is, unlike benzodiazepines, not immediately after ingestion, but only after a few weeks ( two or more) of regular use one. Buspirone has no affinity to the GABA receptors. Presumably, it acts as a partial agonist at 5 -HT1A receptors and as an antagonist at D2 receptors. It was first registered in 1986 for the indication of Generalized Anxiety Disorder.

Side effects

Very common side effects (< 1:10) are dizziness, tiredness, nausea and headaches. Common ( < 1:100) also occurs tachycardia, nervousness, insomnia, paresthesia, diarrhea, difficulty focusing, and depression.

Interactions

Buspirone is metabolized via the cytochrome P450 3A4. This means that the plasma levels of this enzyme buspirone inducers (eg, carbamazepine) decreased or increased by inhibitors (e.g., grapefruit juice, cimetidine).

In connection with strong serotonergic drugs (SSRIs, clomipramine, St John's wort ) may occasionally come to the serotonin syndrome.