Cefazolin

• IUPAC: (6R, 7R ) -3 - [ (5-methyl -1 ,3,4- thiadiazol- 2-yl) - thiomethyl ] -8 -oxo -7- [2 - ( 1H-tetrazol- 1-yl) - acetamido] -5 -thia -1 -azabicyclo [ 4.2.0] oct-2 -ene-2 ​​-carboxylic acid
• Latin: Cefazolinum

• 25953-19-9
• 27164-46-1 (sodium salt)

J01DB04

• β -lactam antibiotic
• The first -generation cephalosporin

Of the bacteria cell wall synthesis is disturbed

Fixed

198-200 ° C ( decomposition)

2.50 at 60 ° C

Poorly in water ( 214 mg · l-1, 25 ° C)

Risk

3000 mg · kg -1 ( LD50, mouse, i.v.)

Template: Infobox chemical / molecular formula search available

Cefazolin is a semisynthetic antibiotic in the class of first generation cephalosporins.

Indication

Cefazolin is used mainly for bacterial infections of the skin. Even in moderately severe bacterial infections of the lungs ( pneumonia and bronchitis), bones, joints, stomach, blood, heart valves, and urinary tract ( renal pelvis, urinary bladder, ureter, prostate gland ) may be used. Another field of application is the use of prophylactic to prevent infection during surgery, such as open heart surgery or surgical procedures on bones and joints.

Action principle

Cefazolin inhibits the development of the cell wall of bacteria. Thus, the pathogen is killed. However, cefazolin is effective only against certain pathogens. For example, against staphylococci, Escherichia coli and Streptococcus pneumoniae. A number of other pathogens, such as Proteus vulgaris, Enterobacter cloacae, and other Streptococcus strains, are highly resistant to cefazolin.

The dominant half-life of normal renal function is two hours.

Applizierung

Cefazolin sodium is injected intravenously or intramuscularly.

Side effects

It will be reported as possible side effects Hypersensitivity reactions and discomfort in the gastrointestinal area (diarrhea, vomiting, nausea ).

Trade names

Basocef (D), Celidocin (D, veterinary medicine ), Kefzol (A, CH), Servazolin (A ), various generics (D, A, CH)