Chlorpropamide

  • Chlorpropamidum
  • 4-chloro- N-( propylcarbamoyl ) benzenesulfonamide

A10BB02

White crystalline powder

Antidiabetic

126-129 ° C

  • Insoluble in water
  • Readily soluble in chloroform and acetone

Attention

  • 2000 mg · kg -1 ( LD50, rat, oral)
  • 580 mg · kg -1 ( LD50, rat, ip)
  • 1039 mg · kg -1 ( LD50, guinea pig, oral)
  • 1546 mg · kg -1 ( LD50, mouse, oral)
  • 800 mg · kg -1 ( LD50, dog, oral)

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Chlorpropamide is a drug of the class of sulfonylureas, which is used for the treatment of diabetes mellitus. It is a white crystalline powder.

History

Chlorpropamide was in Germany in 1958 in the trade and is no longer currently used. In Switzerland it is available since 1978, but only in combination with metformin.

Pharmacology

Pharmacodynamics

Chlorpropamide enhances the effect of the antidiuretic hormone (ADH).

Pharmacokinetics

The half-life in the body is 25-42 hours; the chlorpropamide metabolite are unlikely to be more active. Excretion is almost exclusively as a water-soluble sodium salt in the urine.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Dangerous Substances Directive (67/548/EEC) Intraperitoneal injection Active ingredient
184591
de