Cholesterol side-chain cleavage enzyme

  • OMIM: 118485
  • UniProt: P05108
  • MGI: 88582

Cholesterol - monooxygenase ( P450scc ) (also: 20,22 - desmolase, Cholesterindesmolase ) is the enzyme that catalyzes the conversion of cholesterol to pregnenolone. This reaction step is essential in the biosynthesis of steroid hormones in vertebrates. In humans is the enzyme on the inner wall of mitochondria in the gonads, adrenal glands and located in the brain. Mutations in the CYP11A1 gene can lead to P450cc deficiency and adrenal insufficiency to this.

Variants of the enzyme may be associated with increased risk for relapsed and course of prostate cancer. An earlier association of variants of the CYP11A1 promoter with the occurrence of polycystic ovary syndrome could not be confirmed.

Catalyzed reaction

O2 H2O ⇒

Cholesterol is converted to pregnenolone. The substrate also vitamin D3 is accepted as a product produced 20 ( OH) D3, which causes keratinocytes to divide.

Human Genome Organisation Mouse Genome Informatics Human gonad Promoter (genetics) Digital Object Identifier PubMed Central
184806
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