Chromosome 9 (human)

Chromosome 9 is one of 23 pairs of chromosomes in humans. A normal person has two nearly identical copies of this chromosome in most of its cells.

Decryption of chromosome 9

The chromosome 9 consists of 140 million base pairs. A base pair is the smallest information unit of DNA. Chromosome 9 contains about 4.5 % of the total DNA of a human cell. The identification of the genes on this chromosome is the part of the ongoing process of the human genome. On chromosome 9 are 800-1300 genes. So far, 904 of them are known.

Known genes on chromosome 9

The chromosome 9 includes the following genes:

  • COX -1: cyclooxygenase-1
  • FRDA: frataxin
  • Flavokinase
  • Glycodelin

Medical importance

With the genes located on chromosome 9, inter alia, the following genetic diseases or symptoms are associated:

  • Amyotrophic Lateral Sclerosis
  • Bladder cancer
  • Borderline Personality Disorder
  • Ehlers -Danlos syndrome
  • Friedreich's Ataxia
  • Galactosemia
  • Gorlin - Goltz syndrome
  • Geniospasmus
  • Osler
  • Neuroacanthocytosis
  • Oculocutaneous albinism type 3
  • Osteoonychodysplasie
  • Pleomorphic xanthoastrocytoma
  • Familial Thrombotic thrombocytopenic purpura
  • Tuberous sclerosis

Philadelphia chromosome

See main article Philadelphia chromosome

The Philadelphia chromosome ( Ph1, t (9, 22 ) ( q34, q11 ) ) is a chromosomal aberration in a shortened chromosome 22 by a translocation (exchange) to a chromosomal region of chromosome 9 is formed. Historically, this was the first chromosome change that could be associated with the development of cancer.

Trisomy 9 ( Rethoré syndrome)

See main article trisomy 9

When Rethoré syndrome ( trisomy 9) is in many body cells from a tripling of chromosome 9 by a genome mutation.

Riboflavin kinase PAEP Ehlers–Danlos syndrome Friedreich's ataxia
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