Clobetasol propionate

21- chloro-9 -fluoro- 11β ,17- dihydroxy- 16β - methylpregna -1 ,4-diene- 3 ,20-dione 17-propionate

D07AD01

Glucocorticoids

Risk

• > 3000 mg · kg -1 ( LD50, rat, oral)
• 351 mg · kg -1 ( LD50, rat, ip)

Template: Infobox chemical / molecular formula search available

Clobetasol propionate is a derivative of betamethasone, which is used as a glucocorticosteroid for the topical treatment of inflammatory skin disorders (see, atopic eczema or psoriasis).

Application

Clobetasol propionate belongs as the comparable betamethasone dipropionate Class IV of very potent corticosteroids and is therefore used for short-term treatment of therapy-resistant plaques of inflammatory skin diseases. The effectiveness of clobetasol propionate is increased by a factor of 10 compared to hydrocortisone.

Chemistry

Chemistry and Name

The substance is an ester of propionic acid chemically with the alcohol Betamethasol abbreviated to Betamethasol in which a hydrogen atom is replaced with chlorine. As a result, the name Chlorbetamethasolpropionat.

Physical Properties

Clobetasol propionate is practically insoluble in water, in ethanol 96% ( v / v) low solubility. In this case, a portion of the drug dissolved in 100 parts of ethanol. So it is not available for oral or intravenous administration. When using micro fine powdered clobetasol propionate, the drug dissolves without heating during the emulsion for external use only.

Production

Representation carried out by reaction of betamethasone - 17-propionate with Methylsulfurylchlorid in pyridine and then with lithium chloride in acetone or dimethylformamide.

Safety and security incidents

In case of contact with eyes rinse thoroughly with water. Absorb spilled clobetasol propionate substance with cellulose. Wipe objects with suitable detergent. Skin contact: wash with the undiluted pure substance with water and detergent. Highly contaminated or give work clothes to clean in the wash.

Trade names

CLARELUX (D, A), Clobegalen (D), Clobex (D, A, CH ) Dermovate (A, CH), Dermoxinale (D), Dermoxin (D), Karison (D)