Corticosterone

Colorless, trigonal platelets

Fixed

181 ° C.

Little in water ( 199 mg · l-1 at 25 ° C)

Attention

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Corticosterone is a derivative of pregnane (C21 - steroid) and is formed as a steroid hormone produced in the adrenal cortex.

Effect

In many ways, including in rodents, the main glucocorticoid is corticosterone.

In human, however, it has only a weak glucocorticoid and mineralocorticoid action. It is primarily an intermediate of steroid synthesis from pregnenolone to aldosterone.

Biosynthesis

Corticosterone is produced in the adrenal cortex of progesterone by double hydroxylation (21- hydroxylase and 11β -hydroxylase ).