COX10

• OMIM: 602125
• UniProt: Q12887

The protoheme IX farnesyltransferase ( COX10 ) (also: heme O synthase) is the enzyme in all living organisms, which catalyzes the conversion of heme to heme b o. This is the first of three steps in the metabolic pathway for the biosynthesis of heme A, which acts as a prosthetic group of the cytochrome c oxidase. In eukaryotes, COX10 is found in the intermembrane space of mitochondria. Induced by mutations in the COX10 COX10 gene deficiency is the cause of rare genetic diseases such as cytochrome c oxidase deficiency, or Leigh syndrome.

Together with the protein farnesyltransferase COX10 is one of the prenyltransferases.

Mice in which the gene for COX10 failed to show a degree less amyloid plaques in the brain. Similarly, the values ​​for Abeta42, beta- secretase and oxidative damage were reduced. In a study of a " large number" of patients including a COX10 variant was associated with reduced risk for Alzheimer 's disease.

Catalyzed reaction

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A farnesyl group is added to heme b, heme o arises