CREB-Binding-Protein

OMIM: 600140
UniProt: Q92793

The CREB - binding protein ( CREB binding protein ), short- CBP is a coactivator of transcription.

CBP establishes a connection between the transcription factor CREB, and the transcription start point by a histone acetyltransferase (HAT, EC 2.3.1.48 ) changes the chromatin structure, which is loosened thereby. CBP shows homologies also acting as a HAT protein p300. CBP and p300 acetylate histones H3 and H4 preferred.

CBP is a coactivator of a general nature and interacts with transcription factors, for example.

Clinical Significance

Mutations in this gene are responsible for the Rubinstein - Taybi syndrome ( RTS).

Interactions

The CREB - binding protein has to interact with proteins on the following:

Activating transcription factor 2
Androgen receptor
Autoimmune regulator
BRCA1
BRCA2
C -jun
C -src tyrosine kinase
Casein kinase 2, alpha 1
CCAAT - enhancer - binding proteins
CDX2
CREB1
CSNK2A2
CUTL1
Cyclin - dependent kinase 8

EBF1
Estrogen receptor alpha
EVI1
FOXO1
GLI3
Glucocorticoid receptor
Hepatocyte nuclear factor 4 alpha
HIF1A
HIPK2
HNF1A
HoxB7
ING1
KHDRBS1
KLF13

KLF4
Ku70
MAF
MLL
Mothers against decapentaplegic homolog 1
MSX1
MYB
MYBL2
MyoD
NCOA6
Neurog1
NFATc4
NFE2
NFE2L2

Nuclear receptor coactivator 1
Nuclear receptor coactivator 3
NUP98
P53
PCAF
POLR2A
PPARGC1A
Promyelocytic leukemia protein
PTMA
RBBP4
RELA
RPS6KA3
SERTAD1
Serum response factor

SMARCB1
SMARCA4
SREBF1
SREBF2
SS18L1
STAT1
STAT2
STAT6
TCF3
TGS1
Thymine DNA glycosylase
Transcription Factor II B
TRERF1
Zif268.

Human Genome Organisation Euteleostomi CREB-1 Protein–protein interaction Digital Object Identifier Proceedings of the National Academy of Sciences of the United States of America PubMed Central Oncogene (journal) Nucleic Acids Research The EMBO Journal

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