Crotonyl-CoA

Template: Infobox chemical / molecular formula search available

Crotonyl -coenzyme A, and crotonyl -CoA is the thioester between crotonic acid and coenzyme A.

Crotonyl -CoA is used as metabolite against the degradation of L-lysine and L -tryptophan. In the course of the degradation of these amino acids produced α - Ketoadipat, which is converted by oxidative decarboxylation in glutaryl -CoA. This is reduced by a glutaryl -CoA to crotonyl -CoA dehydrogenase, and finally converted in further steps to two molecules of acetyl -CoA.

Crotonyl -CoA is also a metabolite in the fermentation of glucose by some obligate anaerobic bacteria, in which eventually arises butyric acid. This happens, for example, in the fermentation to obtain Kombucha. In addition, in some microorganisms assimilate the acetate by the ethylmalonyl -CoA pathway known as crotonyl -CoA isolated as an intermediate. It also comes as an intermediate in many metabolic pathways for carbon dioxide assimilation before, such as in 3-Hydroxypropionat/4-Hydroxybutyratzyklus or Dicarboxylat/4-Hydroxybutyratzyklus.