Dimethylallyl pyrophosphate

  • Dimethylallyl -PP
  • Dimethylallyl
  • DMAPP
  • C5H9O7P23 -
  • C5H12O7P2 ( protonated )

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Dimethylallyl pyrophosphate (short- dimethyl- allyl -PP or DMAPP ) is a biomolecule, which can be found as a basic building block in terpene biosynthesis. Chemically, it is one of the isoprenes. It is synthesized in the cytosol by the Mevalonatbiosyntheseweg and formed in the last step by the IPP isomerase from isopentenyl pyrophosphate (IPP). For the participation in the discovery of Mevalonatbiosyntheseweges as well as of cholesterol metabolism 1964 Feodor Lynen and Konrad Bloch received the Nobel Prize for Medicine.

In recent years, a second pathway for DMAPP and IPP was discovered, called the MEP pathway ( Methylerythritolphosphatweg ). This pathway can be found among others in the plant plastids and in Plasmodium falciparum ( the causative agent of malaria). In addition to DMAPP also arises IPP.

DMAPP and IPP are the initial substrates of about 30,000 known until now terpenes. In the human body DMAPP and IPP are the basic substrates in the biosynthesis of hormones or cholesterol.

CAS registry number PubChem Isopentenyl-diphosphate delta isomerase Feodor Felix Konrad Lynen Konrad Emil Bloch Non-mevalonate pathway
240424
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