Dimetindene

  • (RS)- N, N- dimethyl-3- [1 - (2-pyridyl ) ethyl] - 1H-indene -2- ethanamine
  • Latin: Dimetindenum
  • 5636-83-9
  • 3614-69-5 [ dimetindene maleate (1:1) ]
  • D04AA13
  • R06AB03

Oily liquid

Antihistamines

165-175 ° C ( 67 Pa )

Water: 239 mg · l-1 (37 ° C)

618 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Dimetindene is a drug from the group of H1 - antihistamines of the first generation with pronounced anticholinergic effects that is used in the treatment of allergic diseases.

  • 2.1 Mechanism of action ( pharmacodynamics ) 2.1.1 Toxicology
  • 3.1 stereochemistry

Clinical information

Areas of application (indications )

The drug is indicated for the symptomatic treatment of allergic diseases. To the range of indications include further allergic reactions, itching in skin diseases and insect bites, complaints to food allergies and allergies of medical examinations or before anesthesia.

Interactions with other drugs

Concomitant use of tricyclic antidepressants in patients with Dimetindenmaleat can lead to a tendency to glaucoma education to an attack. The effects of alcohol and centrally acting drugs may be enhanced by Dimetindenmaleat.

Pregnancy & Lactation

Although there is no evidence of a teratogenic effect, due to lack of experience with the drug is used by an application - not recommended - especially during the first three months of pregnancy.

Pharmacological properties

Mechanism of action ( pharmacodynamics )

Dimethindene is an antihistamine of the type of the H1 receptor antagonists and inhibit in vitro and in vivo, mediated by histamine H1 - receptors effects. In addition dimetindene is as a potent anticholinergic Muskarinrezeptorantagonist, which makes the off-label use (especially in neurology ) possible.

Toxicology

Poisoning by Dimetindenmaleat express themselves above all by central nervous system symptoms. These range from drowsiness, ataxia and tremor, to tonic- clonic seizures. Moreover, shortness of breath, increased salivation and mydriasis may occur. Acute toxicity of dimetindene are data for rat, mouse, guinea pig and dog before:

Acute toxicity of Dimetindenmaleat:

Chemistry

Stereochemistry

Dimetindene is a chiral drug with a chiral center. Therapeutically is the racemate, the 1:1 mixture of the (S ) - and the (R) -isomer, usually as a salt of maleic acid ( Dimetindenmaleat, CAS number 3614-69-5 ) is used.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System Dangerous Substances Directive (67/548/EEC) Active ingredient Allergy
240728
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