Enantioselective synthesis

As Stereoselective synthesis method is called in chemistry, with which a molecule is built purposefully with a fixed spatial structure, so that one of several possible stereoisomers is formed preferentially.

Target

In addition to the general objective of a chemical synthesis to establish controlled bonds arise in this case one or more new stereocenters. The goal of a stereoselective synthesis is now selective, so vast production of a particular stereoisomer. In a stereospecific synthesis only a pure stereoisomer is formed.

Stereoselective syntheses can be carried out when at least one of the substances participating in the reaction has a unique structure ( configuration). Firstly, natural materials from the chiral pool are used as raw materials or auxiliary materials, on the other hand can, or artificially produced substances are used in a catalytic reaction. A special case of the stereoselective catalysis (with restrictions also called chiral or asymmetric catalysis ) is the use of enzymes. The stereoselective synthesis is particularly useful for the production of biologically active substances and drugs of great importance, since the spatial structure in natural processes is often critical for pharmacological or biological effect, and the general effect of a substance.

Both in industry and in academia, therefore, is the development of new stereoselective syntheses of the most intensively researched areas of modern chemistry, especially organic chemistry.