Endothelin converting enzyme 1

Endothelin converting enzyme ( ECE) is in various tissues of mammals ( including humans ) spread occurring enzyme. Endothelins are formed from its biologically inactive precursor, the prepro- endothelins by proteolytic conversion. The rate-determining step of Endothelinbildung - the enzymatic hydrolysis of the intermediate big endothelin to endothelin - is determined by the endothelin converting enzyme ( endothelin - converting enzyme ) catalyzed.

Endothelin - converting enzyme is a type II protease that belongs to the neprilysin family of zinc - metallopeptidases. From the endothelin -converting enzymes are different isoforms. At present, the importance of the endothelin - converting enzyme in the carcinogenesis of several cancers is discussed (in particular in gynecologic oncology, and in breast cancer ) and in the pathophysiology of Alzheimer's disease.

Protein isoform Human Genome Organisation Metalloproteinase MEROPS Euteleostomi Cell (journal)
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