Enterocytozoon bieneusi

Enterocytozoon bieneusi is an entity belonging to the microsporidia species, which can infect obligate intracellular parasite as intestinal epithelial cells.

The first description and wording was 1985.

Laboratory investigations are hampered by difficulties in culturing. Therefore, initially outweighed microscopic methods ( the spores are up to 1.6 microns in size ). Meanwhile, you can cell cultures thereby creating that one takes potential host cells by aspiration or biopsy and are on a monolayer of kidney cells from Western vervet monkeys. This is followed by the inoculation, after which form spores within a few weeks. But microscopic methods using fluorescent dye are easier and faster for the examination of stool samples and are therefore preferred.

The organism is a eukaryote, but has not yet mitochondrial ribosomes. Like other Microspora also provides a pile thread establishes the contact of Enterocytozoon spore to the host cell, which then can penetrate into the cytoplasm these. Daughter nuclei then the intruder can arise by merogony. After this multiplication follows the sheath of the new core material, ie the formation of new spores. The pile thread has a certain number of Polarfilamentwindungen, which is a distinctive feature of the other Microspora species.

Clinic

As hosts are animals such as pigs ( there often, self-limiting diarrhea causing ) into consideration. Since the organism was also detected in moats, is close to a fecal- oral transmission via manure. From the people immunocompromised individuals are susceptible ( there cholangitis or diarrhea causing ). Until the spread of AIDS this parasite had only a limited distribution in humans.

One approach to treatment is the biosynthesis of chitin, so that albendazole and fumagillin come into question.