Estramustine

17β - hydroxyestra -1, 3,5 (10 )-triene -3-yl N, N- bis (2- chloroethyl ) carbamate

L01XX11

Cytostatic

104-105 ° C

Template: Infobox chemical / molecular formula search available

Estramustine (trade name: Estracyt among others, Manufacturer: Pharmacia and others), is an antineoplastic agent in the structurally combines an alkylating agent ( alkylating agents, nitrogen mustard derivative) and estrogen ( estradiol ) is present ( dual mechanism of action ).

Pharmacology

Application

Use it finds in the secondary treatment of advanced prostate cancer.

Side effects

As with other cytotoxic agents also guided the side effects especially of the inhibitory effects on rapidly dividing cells of the body from:

  • Gastrointestinal disorders
  • Edema
  • Heart failure
  • Thromboembolism
  • Libido and potency loss
  • Changes in blood
  • Liver damage

Trade names

Cell Mustin (D), EstraCept (D), Estracyt (D, A, CH), Medactin (D), Multosin (D) and a generic (D)

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Pfizer Alkylating antineoplastic agent Complete blood count Nimustine
317478
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