Ethyl biscoumacetate
- Bis (4- hydroxy-2 -oxo -2H- chromen- 3-yl) - acetic acid ethyl ester
- Ethyl-2 ,2-bis (4-hydroxy -2-oxo -2H- chromen- 3-yl ) acetate
B01AA08
Bimorph crystals
Anticoagulants
Vitamin K antagonist
177-182 ° C and 154-157 ° C
3.1
- 750 mg · kg -1 ( LD50, mouse, oral)
- 840 mg · kg -1 ( LD50, rat, oral)
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Ethylbiscoumacetat is the international non-proprietary name of bis (4-hydroxy -2-oxo -2H- chromen- 3-yl) - acetic acid ethyl ester, a chemical compound from the group of 4- hydroxycoumarins with anticoagulant effect.
- 3.1 Mechanism of action ( pharmacodynamics )
- 3.2 Absorption and distribution in the body ( pharmacokinetics )
Chemistry
Ethylbiscoumacetat crystallizes in two different forms ( Bimorphismus ) which differ by their melting point.
Clinical information
Areas of application (indications )
It is used for the controlled anticoagulation, for example in the treatment or prevention in a tendency to thrombotic diseases.
Adverse effects (side effects)
As a possible side effect Ethylbiscoumacetat can facilitate bleeding and hematoma due to its inhibition of coagulation, but there may also be fever, nausea and diarrhea or rash of the skin.
Pharmacological properties
Mechanism of action ( pharmacodynamics )
It exerts its protein anticoagulation by inhibiting the enzymatic reduction of vitamin K. It acts just like any other Coumarinvarianten, such as acenocoumarol, dicoumarol or warfarin.
Uptake and distribution in the body ( pharmacokinetics )
Ethylbiscoumacetat is taken orally and is finally largely absorbed by the body. In the circulation and bind it to 95% of the modified proteins of the blood plasma, and finally it is reduced again by the liver.