Flucloxacillin

(2S,5R,6R)-6-{[3-(2-Chlor-5-fluorphenyl)-5-methyl-oxazol-4-carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carbonsäure (IUPAC)

• 5250-39-5
• 1847-24-1 (sodium salt)

• J01CF05
• QJ51CF05

Isoxazolylpenicillin

Cell wall synthesis inhibition, bactericidal

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Flucloxacillin is a penicillinase- β -lactam antibiotic that has been specially designed against β -lactamases forming staphylococci and is therefore referred to as a staphylococcal penicillin.

It belongs to the group of Isoxazolylantibiotika which include cloxacillin (none in Germany approved for humans preparations), dicloxacillin and oxacillin belong. The agent Cloxacillin is featured on the list of essential drugs of the World Health Organization and can be replaced according to the WHO with an agent of the same group of substances or of the same spectrum of activity. This product is in Germany flucloxacillin or oxacillin. This also penicillinasefeste methicillin is used only to susceptibility testing for MRSA and MRSE; these germs are not treatable with flucloxacillin.

Indication

Flucloxacillin is used for treating infections caused by β -lactamases forming staphylococci - both gram positive and gram negative - indexed. Flucloxacillin is good tissue penetration, cross the placental barrier and is excreted in breast milk. Frequent application takes place in infections of skin, mucous membranes and soft tissues - such as boils and abscesses, pyoderma and paronychia - as well as the respiratory tract, bones and bone marrow. Most enterococci are resistant to flucloxacillin.