Fotemustine

  • (RS) -diethyl- (1 - {[( 2-chloroethyl) ( nitroso ) carbamoyl ] amino } ethyl ) phosphonate
  • (RS ) -1 - (2- chloroethyl ) -3 - (1- diethoxyphosphorylethyl )-1 -nitrosourea (IUPAC)
  • S 10036

L01AD05

Yellowish powder

Cytostatic

Fixed

85 ° C.

Attention

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Fotemustine, chemically 1 - (2 -chloroethyl ) -3 - (1- diethoxyphosphorylethyl )-1 -nitrosourea (trade name Muphoran ) is the generic name for a cytostatic agent from the group of nitrosoureas. It is approved for the treatment of disseminated metastatic melanoma.

Pharmacology

Mechanism of Action

Fotemustine changed as nitrosoureas all the genetic material in the cell nuclei. This causes the affected cells can no longer divide and die after some time. From the genomic damage are essentially rapidly dividing cells - especially cancerous cells - affected. Fotemustine is able to overcome the blood- brain barrier. This is in the treatment of melanoma with CNS metastasis advantageous.

Side effects

Fotemustine is myelotoxic, meaning it damages the bone marrow. This damage has a negative effect on blood formation, especially the platelets and leucocytes. In addition, nausea and hair loss are the main side effects.

Fotemustine is - like all nitrosoureas - carcinogenic itself, that is carcinogenic.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Dangerous Substances Directive (67/548/EEC) Dissemination
343703
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