Fructose 1,6-bisphosphate

• Diphosphofructose
• Fosfructose
• F-1 ,6 -BP
• Harden -Young ester

• 488-69-7
• 41012-14-0 (sodium salt)

Colorless solid

Fixed

50 mg · ml -1 water

Template: Infobox chemical / molecular formula search available

Fructose-1 ,6 -bisphosphate (F-1 ,6 -BP ) is a phosphorylated sugar in metabolism ( glycolysis) plays an important role as an intermediate. The β -D - form is the isomer in nature's most abundant. It must not be with fructose -2 ,6 -bisphosphate, a very similar metabolites with regulatory activity, confused.

History

One of the earliest scientific references is from 1933, which examined the intermediates of glycolysis. At this time, the compound was designated as Fructosediphosphorsäure. The prefix " up " is used today as it is correct. This indicates that the two phosphate groups are not connected to each other and located on two different atoms.

Biological Significance

Fructose-1 ,6 -bisphosphate is an important intermediate in Kohlenhydratstoffwechel, such as the degradation of glucose. It is formed as part of the glycolysis of fructose -6-phosphate, which is phosphorylated by a phosphofructokinase with consumption of ATP. An aldolase splits in the subsequent reaction of fructose -1 ,6 -bisphosphate into two C3 building blocks: glyceraldehyde -3 -phosphate and dihydroxyacetone phosphate.

Also in the construction of glucose ( gluconeogenesis ) F-1 ,6 -BP is formed. This is then converted into fructose -6-phosphate, which is then further processed into glucose-6 -phosphate.

Finally, it can also regulate the pyruvate kinase F-1 ,6 -BP: The Pyruvatkinasen the liver, the kidney and in the red blood cells are activated ,6 -bisphosphate allosterically by fructose -1.