Galactosylceramidase

Galactocerebrosidase (also: galactosylceramidase ) is the enzyme in vertebrates, cleaves the galactose of galactocerebrosides. The reduction of these glycolipids, which are a part of the myelin, takes place in the lysosomes of cells. Mutations in the GALC gene in humans are the cause of a deficiency of this enzyme, and this hereditary for a rare metabolic disorder, the Krabbe disease.

Galactocerebrosidase is a member of family 59 in the classification of glycosidases by Henrissat.

Protein isoform Human Genome Organisation Digital Object Identifier
359086
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