Gastric inhibitory polypeptide

  • OMIM: 137240
  • MGI: 107504

The glucose -dependent insulinotropic peptide ( GIP), formerly known by the same acronym as Gastroinhibitorisches or peptide Gastrointestinal inhibitory peptide consists of 42 amino acids and is in the K cells of the duodenum (duodenum ) formed peptide hormone.

Before the neutralization of the gastric acid (see, pH value) and the slowing of gastric emptying was considered to be the main action. These effects are observed but only at non-physiologically high concentrations of GIP, but usually they are by another hormone, namely controlled secretin.

Today is detected after food intake as a main effect, stimulation of insulin secretion in the B-cells of the pancreas ( pancreatic ). Inhibition of GIP activity reduces the development of obesity and insulin resistance in a high-fat diet. It is believed that GIP with decreasing insulin action a crucial role in the change of fat oxidation plays to fat storage. So it could play an important role in the secondary prevention of insulin resistance.

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