Glucokinase regulatory protein

The protein called glucokinase regulator ( GCKR ) is formed in humans and all vertebrates in the liver and pancreas. GCKR reversibly binds to the enzyme glucokinase. After translocation into the nucleus of the complex is separated with a high level of glucose, and again made ​​into the cytosol glucokinase. The effect is that at low glucose levels, a pool of GK: GCKR is ready in the nucleus to catch fast elevated glucose levels after food intake.

Binding is stimulated by fructose -6-phosphate, and sorbitol -6-phosphate, but inhibited by fructose-1 -phosphate. So the latter increases glucokinase acivity.

A genetic variant of the protein, which occurs in 34 percent of non-Europeans, is associated with increased CRP and triglycerides, and decreased glucose during fasting. A further study with European-born Canadians associated elevated triglycerides during fasting with a GCKR variant. A French study gave identical results.

Human Genome Organisation Euteleostomi C-reactive protein Digital Object Identifier Human Molecular Genetics Diabetologia
269534
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