Glucose 1-phosphate

  • Glc -1P
  • G1P
  • Cori ester
  • 59-56-3
  • 6736-77-2 (potassium salt)

Colorless solid (potassium salt)

Potassium salt

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D-glucose -1-phosphate (also known as Cori ester) is phosphorylated at the carbon atom C1 of the form D-glucose and an isomer of D-glucose -6-phosphate. In many metabolic steps, it plays an important role.

Biological Significance

Glucose- 1-phosphate is involved in several metabolic pathways. In glycogen is formed from glycogen by phosphorolytic cleavage, which is a glycogen phosphorylase catalyzes. Isomerization can be isomerized by a further processing of glucose -1-phosphate into glucose -6-phosphate, this reaction is reversible and is catalysed by a phosphoglucomutase.

Another important reaction is the formation of UDP- glucose from α -D-glucose -1-phosphate and UTP by UTP - glucose-1- phosphate uridyl transferase ( Gult, EC 2.7.7.9 )

UDP -glucose not only plays a role in glycogen metabolism, but also in Galactosestoffwechsel and Uronsäurenstoffwechsel.

Alongside UTP and other nucleotides such as dTTP, ATP, CTP and GTP, can be linked to glucose-1 -phosphate. Be catalyzed these reactions by various transferases ( EC 2.7.7.24, EC 2.7.7.27, EC 2.7.7.33 and EC 2.7.7.34 ).

CAS registry number PubChem Gerty Cori Glycogenphosphorylase Uridine diphosphate glucose Uridine triphosphate Adenosine triphosphate Cytidine triphosphate Guanosine triphosphate
269635
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