GLUT-2

GLUT -2 ( glucose transporter type 2) ( gene: SLC2A2 ) is the name for a glucose transporter. GLUT -2 is localized in the cell membrane of several cell types of mammals and enables insulin- independent import or discharge of glucose. In humans is produced mainly in the liver, pancreas and small intestine and the kidney GLUT -2. Mutations in the SLC2A2 gene may render the protein useless; this causes the rare Fanconi -Bickel syndrome.

Function

The task of GLUT -2 in the small intestinal mucosa, it is usually to smuggle over SGLT1 and GLUT -5 absorbed from the intestinal lumen, glucose, galactose and fructose into the blood. However, the GLUT -2 localized to the high glucose and food apical ( into the intestinal lumen ), thereby increasing the uptake of glucose by diffusion. Similar to SGLT1 reabsorbed GLUT -2 in the renal glucose back.

In the beta cells of the pancreas but also in the brain, GLUT -2, apart from the ease of glucose uptake, may be part of the measuring apparatus of the glucose level.

Human Genome Organisation Major facilitator superfamily SLC5A1 Digital Object Identifier
269533
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