GLUT-3

GLUT -3 ( glucose transporter type 3) ( gene: SLC2A3 ) is called the protein that is localized particularly in the cell membrane of neurons of animals and facilitates the input and discharge of glucose and of dehydroascorbate. Is a membrane transport protein. In humans, GLUT -3, to a small extent also in many other types of tissue present. In the house mouse (Mus musculus), it is one of the most common proteins in the sperm.

The phylogenetically oldest copy was found in Nematostella vectensis, a sea anemone.

Function

In neurons, the expression of GLUT -3 is regulated by activity of the AMP - kinase. This process is an important part of the insensitivity of neurons to excitotoxicity ( over-activation of glutamate receptors). Even in the early stages of development of the embryo is GLUT -3 essential.

Further Reading

  • Maulen NP, Henríquez EA, Kempe S, et al.: Up -regulation and polarized expression of the sodium - ascorbic acid transporter SVCT1 in post- confluent differentiated Caco -2 cells. In: J. Biol Chem 278, No. 11, March 2003, pp. 9035-41. . doi: 10.1074/jbc.M205119200. PMID 12,381,735th
  • Rumsey SC, Kwon O, Xu GW, Burant CF, Simpson I, Levine M: Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. In: J. Biol Chem 272, No. 30, May 1997, pp. 18982-9. . PMID 9,228,080th
  • Liang WJ, Johnson D, Jarvis SM: Vitamin C transport systems of mammalian cells. In: Mol Membr. Biol. 18, No. 1, 2001, pp. 87-95. PMID 11,396,616th
  • Rivas CI, Zúñiga FA, Salas - Burgos A, Mardones L, Ormazabal V, Vera JC: Vitamin C transporters. In: J. Physiol. Biochem .. 64, No. 4, December 2008, pp. 357-75. PMID 19,391,462th
Human Genome Organisation Major facilitator superfamily Transportprotein Starlet sea anemone Digital Object Identifier PubMed Central
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