GLUT-5

The Fructosetransporter ( GLUT5 ) ( gene: SLC2A5 ) is that protein in the cell membrane of epithelial cells of chordates, that accomplishes the intake of fructose by means of facilitated diffusion ( passive transport ) into the cell. It is a transport protein. GLUT5 is formed in humans, mainly in the small intestine and in the sperm, and to a lesser extent in the kidneys, muscle and fat cells. There is nothing known about mutations in the SLC2A5 gene.

Function

The transport equation is:

It is a uniport.

Regulation

The fructose uptake rate by GLUT5 is significantly affected by diabetes mellitus, hypertension, obesity, fructose malabsorption, as well as inflammation. However, age-related changes in the fructose intake capability is not explained by the rate of expression of GLUT5. The Fructoseresorption is still in the simultaneous presence of glucose enhanced while sorbitol is inhibitory.

Human Genome Organisation Major facilitator superfamily Transportprotein Digital Object Identifier
269570
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