Glutathione peroxidase

  • CAS Number: 9013-66-5

The glutathione peroxidases catalyze the glutathione - dependent reduction of organic peroxides and hydrogen peroxide. In the catalytic center wearing L- selenocysteine ​​, a derivative of L- serine and L- cysteine. The phospholipid hydroperoxide glutathione peroxidase belongs to the family of glutathione peroxidases.

Special importance attaches to glutathione peroxidases as part of the cellular defense against the consequences of oxidative stress. Disturbances in the function of these selenoproteins are associated with syndromes such as Keshan and Kashin - Beck disease and may play a role in tumor formation in atherosclerosis and - in conjugation with 4- Hydroxynonenalen - play in neurodegenerative diseases

Catalyzed reaction

Hydrogen is transferred from glutathione in hydrogen peroxide. Glutathione is oxidized.

GPS Exchange Format Human Genome Organisation CAS registry number Organism GPX4 Keshan disease Conjugated system 4-Hydroxynonenal
269562
de