GMP reductase

• OMIM: 139 265
• UniProt: P36959

GMP reductase ( GMPR ) are called enzymes in eukaryotes and bacteria, catalyze the deamination of GMP to IMP. These reactions are used for recovering and maintaining the balance of purine nucleotides in the cell.

People have two genes encoding GMPR ( GMPR and GMPR2 ), each generating two splice variants. GMPR2 may have a further function in the differentiation of monocytes.

Catalyzed reaction

NADPH / H NH3 NADP

From GMP eliminates ammonia and IMP produced. The reaction is irreversible.