Gorham's disease

The Gorham - Stout syndrome, also Gorham - Stout disease or English vanishing bone disease called, is to resolve an extremely rare disease in which bones and replaced by lymphoid tissue. The Gorham - Stout syndrome was first in 1955 by the American pathologist L. Whittington Gorham ( 1885-1968 ) and Arthur Purdy Stout ( 1885-1967 ) described, after which the disease is named.

Etiology

The cause of the Gorham - Stout syndrome is still largely unclear. Interleukin -6 obviously plays an essential role as a messenger in the disease. It is presumed increased osteoclastic activity or angiomatosis. The disease is extremely rare. There are about 200 documented cases.

Complications

• Chylothorax
• Infection of the spine

Therapy

There is currently no generally accepted treatment regimen for the Gorham - Stout syndrome. The administration of bisphosphonates, interferon alpha 2b, radiation and chemotherapy, and surgery ( pleurodesis in the case of a chylothorax ) are described as interventions.