Halomon

(3S, 6R)- 6-bromo- 3-( bromomethyl) - 2,3,7 -trichloro -7-methyl -1-octene

Fixed

49-50 ° C

Template: Infobox chemical / molecular formula search available

Halomon is a chemical compound belongs to the group of the halogenated monoterpenes and has a strong and selective toxic effect on tumor cells. Since it occurs in red algae, it is one of the phytochemicals.

History, occurrence, production

Halomon was discovered in 1992 along with other halogenated monoterpenes in the red alga Portieria hornemannii. The extraction of Halomon from the red alga turns out to be very costly and not very promising, since not all strains of this alga Halomon produce, and it also comes within a tribe to strong fluctuations in the Halomonproduktion. For the extraction of approximately 400 mg Halomon therefore one needs about 2 to 4 kg of this delicate red algae. In addition to the Halomon but fall in the extraction of other structurally related compounds, some of which also show a strong toxic effect on tumors.

In the years 1997 to 2000, several synthetic routes have been described for Halomonstruktur.

Pharmacology

Halomon one of the few substances showing a toxic effect in all 60 tumor cell lines of the National Cancer Institute. As leukemia and melanoma cell lines are less sensitive, show brain, kidney and colon cancer cells, up to a hundred times higher response.

Credentials

• Terpene
• Chloroalkane
• Bromoalkane
• Chloroalkene
• Phytochemicals