Human Proteome Folding Project

The Human Proteome Folding Project is a World Community Grid project for distributed computing. Establishments is the project of New York University, the Institute for Systems Biology in Seattle and the University of Washington. The aim of this project is the de novo structure prediction of human proteins. For the algorithm, the software finds the Rosetta @ home project application that is considered as very favorable results in the CASP competition as very powerful. Currently running after the completed Phase 1, a so-called phase 2, are examined in more detail in the medically particularly important proteins.

On 10 July 2007 it was announced that the first malaria - relevant data have been calculated successfully in proteins.

The project is based on the BOINC infrastructure. Formerly a separate client was used, which was however discontinued. The infrastructure of the project was sponsored by IBM, is however not itself a commercial project, as all results must be publicly available.

Publications

• Malmstrom L, M Riffle, CE Strauss, Chivian D, Davis TN, Bonneau R, Baker D.: Superfamily Assignments for the Yeast Proteome through Integration of Structure Prediction with the Gene Ontology. In: PLoS Biol, 2007 Mar 20, 5 ( 4 ), pp. e76.
• R Bonneau, MT Facciotti, DJ Reiss, AK Schmid, M Pan, A Kaur, V Thorsson, P Shannon, MH Johnson, JC Bare, W Longabaugh, M Vuthoori, K Whitehead, A Madar, L Suzuki, T Mori, DE Chang, o J Diruggier, CH Johnson, L Hood, NS. Baliga: A predictive model for transcriptional control of physiology in a free living cell. In: Cell, 2007 Dec 28, 131 (7 ), pp. 1354-1365, PMID 18,160,043th