Hypoglycin

  • Hypoglycin A
  • 2- Methylenecyclopropanylalanin
  • L-( S)-2 -amino-3 -(2- methylidenecyclopropyl ) propionic acid
  • L- (S )-2- amino-3- [(S )-2- methylidencyclopropyl ] -propionic acid
  • ( αS, 1R ) - α -amino-2 - propionic acid methylidencyclopropyl

280-284 ° C

Template: Infobox chemical / molecular formula search available

Hypoglycin is a non- proteinogenic amino acid found in the seeds and unripe fruit of the ackee plant. In the immature seed coat occurs up to 1000 ppm Hypoglycin; This is equal to 1 mg per gram of wet weight. In the seeds, it is 2-3 times as much.

Poisoning

When consumed it comes to severe symptoms of poisoning, which can range from vomiting ( Jamaican vomiting sickness ) lead to low blood sugar, fatigue symptoms, coma and death. Symptoms show up 6-48 hours after ingestion. The cause of the poisoning is the inhibition of acyl -CoA dehydrogenases. Will also discuss the inhibition of oxidation of fatty acids and leucine. The effect is probably not caused by Hypoglycin itself but by its primary metabolite Methylenecyclopropylacetyl -CoA ( MCPA -CoA).

CAS registry number Aril Digital Object Identifier
405077
de