Indazole

Colorless solid

Fixed

147-149 ° C

270 ° C ( 994 hPa)

Soluble in water

Template: Infobox chemical / molecular formula search available

Indazole is an aromatic heterocycle, forming the backbone of only a few natural substances ( nigellicin, nigellidin and Nigeglanin from Nigella sp.).

Occurrence

Derivatives of indazole are rare in nature. Nigellicin, Nigeglanin and nigellidin are three natural substances that contain the indazole ring. Nigellicin is an alkaloid derived from Nigella sativa L. ( black cumin ) and belongs to the class of Sogn. mesomeric betaines. Nigeglanin was isolated from Nigella glandulifera.

Representation

The preparation of indazoles for example, via the so-called " Indazolsynthese Jacobson " (See rough diagram below).

Use

Indazole has importance for the production of certain dyes. Derivatives of the indazole can also be of interest in pharmacology, the 1 -benzyl-3 -(3- dimethylaminopropoxy ) -1H -indazole is ( benzydamine ) used for its anti-inflammatory and local anesthetic effects in painful inflammation of the mucous membranes.