Inflammation#Cell derived mediators

Inflammatory mediators are endogenous substances that initiate or maintain an inflammatory response of the body.

The inflammatory mediators include both low molecular weight compounds, such as histamine, serotonin, prostaglandins and leukotrienes as well as high molecular weight peptide substances or proteins, such as bradykinin, substance P, calcitonin gene-related peptides, complement and cytokines.

In particular mediated by inflammatory mediators effects include effects on cells of the immune system, such as chemotactic recruitment of leukocytes, cellular proliferation, and degranulation of mast cells and basophils, a. In addition, they can effect on blood vessels (for example, dilatation and increased permeability ) with edema show.

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• Immunology