Insulin receptor substrate

  • OMIM: 605 ​​475
  • UniProt: Q9UQB8

The insulin receptor substrate ( IRSp53 ) (also: brain- specific angiogenesis inhibitor 1 -associated protein 2 ( BAP2 ), gene name: BAIAP2 ) is a structural protein in vertebrates. As cytoskeletal adapter it simultaneously binds to membrane-bound small G proteins and cytoplasmic effector. Its presence is necessary in the reorganization and regulation of the actin cytoskeleton as well as in the growth of neurites and filopodia.

By the binding of a phosphotyrosine IRS domain of the activated insulin receptor and phosphorylation of IRS by the kinase activity of the receptor is to bind it to the other signal transduction IRS. The more important for signal transduction, the effect of insulin is the PI3 kinase.

Protein isoform Human Genome Organisation Digital Object Identifier Nature Reviews Molecular Cell Biology Protein domain
413646
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