Interleukin 8 receptor, alpha

• OMIM: 146 929
• UniProt: P25024
• MGI: 2448715

CXCR1 (short for CXC motif chemokine receptor 1, also IL- 8 receptor alpha ( IL- 8RA ) CDw128a, CD181 ) is a receptor protein of the family of chemokine receptors. CXCR1 is especially at the surface of cells of the immune system such as neutrophils and macrophages, above. This receptor can be obtained by the chemokines CXCL6 (GCP -2 ), and CXCL8 ( interleukin- 8) are stimulated and mediates its effects by means of activation of an intracellular signal transduction at the Gi proteins are involved. CXCR1 is ascribed an important role in the pathogenesis of inflammatory diseases and tumor growth.

Occurrence

CXCR1 can in particular neutrophilic granulocytes and macrophages, but also eosinophils, basophils, dendritic cells and T lymphocytes are detected.

Biochemistry

CXCR1 structurally belongs to the G protein- coupled receptors. After connection of its ligands activates a signal transduction within the cell, are involved in the G- proteins, Ca2 and MAP kinases. The signal transduction cascade also includes activation of integrins and changes in the cytoskeleton. These are prerequisites for targeted movement (chemotaxis ) of CXCR2 -expressing cells to a chemokine gradient toward.

Function

The function of CXCR1 is similar to that of his relatives CXCR2. Both receptors are also often expressed on the same cell types. In the presence of the common ligand CXCL8, the role of CXCR1 regarding the chemotaxis of neutrophils, the superoxide production and Signaltransduktionsaktivierung dominate.