Kyotorphin

L- tyrosyl -L- arginine

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Kyotorphin (L- tyrosyl -L- arginine) is a neuro- physiologically active dipeptide, which plays a role in pain regulation in the brain. It was established in 1979 as the first isolated by Japanese scientists from bovine brains ( Bovinae ). It owes its name to the city of Kyoto, in which it was discovered.

Effect

Kyotorphin has an enkephalin and morphine-like analgesic effect. However, it does not interact with opioid receptors. It uses Opiodpeptid, Met- enkephalin, free and stabilizes it against its degradation. It may also owns the properties of neurotransmitters, neuro- mediators or neuromodulators. It has been shown that occurs in the human brain kyotorphin liquid and that it is present in patients with persistent pain in a smaller amount.