Lanthanum carbonate

Lanthanum carbonate

V03AE03

White odorless solid

Phosphate binders

Fixed

Insoluble in water

Attention

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Lanthanum is a chemical compound (specifically, a carbonate of lanthanum ), which is used to produce fuel cells, and in medicine.

Use

Technology

Lanthanum carbonate lanthanum strontium manganate is used for the production, which is mainly used in fuel cells are used. Furthermore, it is used to color the glass and as a catalyst in cracking.

Medicine

In medicine it is used as a phosphate binder. It is in Germany under the trade name Fosrenol ® since November 2006 in the trade and is marketed by Shire Pharmaceuticals. Fosrenol ® is over the counter and prescription, and is used in patients with ESRD for the treatment of hyperphosphatemia (elevated phosphate levels ) applied. As a calcium-and aluminum-free phosphate binder lanthanum carbonate has the same strength as aluminum phosphate binding, without so far to show its toxicity in the long-term use. However, acute side effects occur frequently. In the long-term use of this heavy metal also far only limited data are available. Discussed is present, the relevance of the absorption of lanthanum in the body and its accumulation in the organs (bone, liver, etc. ) has. The clinical relevance of crossing the blood -brain barrier and accumulation of lanthanum in the brain in experimental animals is diskutiert.Lanthan should be taken with or after a meal to bind phosphate in the diet as lanthanum phosphate in the gastrointestinal tract and thus to prevent absorption of the phosphate in the body.

Veterinary Medicine

In veterinary medicine, particularly in the treatment of chronic renal insufficiency cats Lanthanum carbonate octahydrate (product name Lantharenol ®) for the support of renal function in cats with chronic renal failure (CRF ) is used. Lanthanum carbonate octahydrate is available from October 2008 in the diet supplement feed Renalzin ® (Bayer Healthcare) included for renal failure cats.

Studies have shown that Lantharenol already at the lowest recommended dose resulted in a significant decrease in phosphate uptake. The excretion of phosphates in the faeces and the decrease in excretion through the kidneys stood for a dose of medication and the phosphorus content of the feed in direct correlation.

So far, neither side effects nor intolerance of Lantharenol in cats occurred. No side effects in studies in cats could be provoked with ten times the recommended dose of over two weeks. However, still standing from observations and studies on the long-term effects of Futtersupplementierung with Lantharenol.