Licochalcone A

3- dimethylallyl -4, 4'- dihydroxy-6 - methoxychalcone, LICA

Yellow crystalline solid

Attention

Template: Infobox chemical / molecular formula search available

Licochalcone A is a chemical compound, a so-called flavonoid selected from the roots of Chinese licorice (Glycyrrhiza inflata ) can be extracted. In addition to the known anti-inflammatory effect could previously antibacterial in laboratory studies, anti-parasitic and anti-cancer effects are detected.

Occurrence

The Süßhölzern licochalcone A occurs only in the species G. inflata and G. eurycarpa what makes it a distinguishing feature to the very similar G. glabra and G. uralensis.

Licochalcone A was further in Indian patchouli ( Pogostemon cablin ) and Pleurospermum hookeri var thomsonii, an umbelliferous found.

Synthesis

About the biosynthesis of licochalcones is not yet known. For the synthesis in the laboratory have to be Aussgangssubstanzen prenylated benzaldehydes to.

Pharmacology

Licochalcone A inhibits in different skin cells, the release of inflammatory mediators such as NF -kB. The activity against Plasmodium comes about due to an irreversible change of red blood cells. The active ingredient is used, among others, in skin care products for eczema and in cosmetics for sensitive skin.