Ambers first came in a basement of a is contained in a church of his hometown training center with the boxes in contact. When his family had in the Great Depression close her restaurant, he worked in a furniture factory and then made 1932 boxes to his profession. He was trained there and managed as Rocky Marciano later by the same team.
He lost in his first 32 fights at lightweight with clean counter boxes only once and received by Ring Magazine after a year a ranking placement.
On May 10, 1935, he fought for the vacant World Championship to be also Italo American model Tony Canzoneri, whose sparring partner he had been before. Canzoneri won the duel at New York's Madison Square Garden on points.
In his next fight Ambers scored a victory over Fritzie Zivic. After a further 13 victories, he punched again on September 3, 1936 against Canzoneri and won the world title in his turn by a points victory.
In November 1936, he defeated the legendary welterweight Jimmy McLarnin in a non-title fight. In 1937 he defended his title twice, including a third duel against Canzoneri.
He subsequently went on August 17, 1938 against Henry Armstrong and lost the World Cup just on points, was the rematch a year later supported by five point deductions against Armstrong decide for themselves. This was the only defeat Armstrong in the years 1937 1940.
More victories come against Ambers Baby Arizmendi and Al " Bummy " Davis. The world title he lost on 10 May 1940 by TKO in the third round, the first early defeats of his career, to the hard-hitting Lew Jenkins. After another early defeat against Jenkins in February 1941, he finished his career.
In 1992, Amber's induction into the International Boxing Hall of Fame.