Macrophage colony-stimulating factor

M -CSF (of English. Macrophage colony-stimulating factor, dt Monozytenkolonien - stimulating factor), and 1 CSF - called, is an endogenous protein from the group of cytokines. It causes particular that of blood stem cells, mononuclear phagocytes, such as macrophages and monocytes, mature. At the molecular level, this effect is attributed to the activation of the CSF1 receptor. This receptor cells bear all mononuclear phagocytic - origin, such as mononuclear phagocytic precursor -, monocytes, macrophages, osteoclasts and microglia.

Structure

M-CSF is a protein located extracellularly and in its active form as disulfide -linked homodimer. It is believed that it is formed by proteolysis of the membrane-bound precursors.

Interactions with other proteins

An interaction of M-CSF with PIK3R2 was detected.

Locally produced in the vessel walls M -CSF contributes to the formation as well as to the course of atherosclerosis.

M-CSF is associated with male fertility.

Protein isoform Human Genome Organisation Hematopoietic stem cell Protein–protein interaction Protein domain PubMed Central
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