Metabotropic glutamate receptor 1

The acronym refers to mGluR1 in cell physiology and neurobiology metabotropic glutamate receptor subtype 1 Together with mGluR5 ( metabotropic glutamate receptor subtype 5), it forms the group 1 metabotropic glutamate receptors.

MGluR1 and mGluR5 in common is that they upon binding of glutamate via a G protein to activate phospholipase C ( from the family Gq ). This cleaves phosphatidylinositol -4 ,5 -bisphosphate ( PIP2 ) to inositol triphosphate (IP3 ) and diacylglycerol (DAG ). IP3 releases via its specific receptor in the membrane of the endoplasmic reticulum (ER) calcium ions in the cytoplasm, while DAG activates protein kinase C.

Dihydroxyphenylglycine ( DHPG ) represents another agonist of mGluR1 and mGluR5 dar.

Like other metabotropic receptors mGluR1 a membrane protein with five α -helical transmembrane domains.

MGluR1 is located in the central nervous system at many synapses is highest its expression at the parallel fiber synapses of the Purkinje cells in the cerebellum. The C-terminal end of the protein is responsible for its localization. In this region of the protein structure, there are domains that bind the receptor in the dendrites. These domains are used in the structure of mGluR1 before redundancy. For its postsynaptic localization, however, for example, is the binding site responsible for the postsynaptic protein Homer.

Protein isoform Human Genome Organisation Phosphatidylinositol 3,4-bisphosphate Proteinkinase C
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