Methysergide

  • IUPAC: 1- methyl-D- lysergic acid -(1- hydroxybutyric -2-yl ) amide
  • 361-37-5
  • 129-49-7 ( maleate )

N02CA04

Colorless to pale-yellow solid ( maleate salt)

194-196 ° C

  • 2 mg · ml -1 in water ( maleate )
  • > 10 mg · ml -1 in DMSO ( maleate )
  • > 20 mg · ml -1 in methanol ( maleate )

Risk

440 mg · kg -1 ( LD50, mouse, oral)

Template: Infobox chemical / molecular formula search available

Methysergide is a drug which has been used in the prophylactic treatment of migraine. It acts as an antagonist or partial agonist at various serotonin receptors ( 5-HT receptors). Its migraine prophylactic effect was particularly associated with an inhibition of 5 - HT2B. Due to severe side effects, especially Retroperitonealfibrosen, Pleuralfibrosen and valvular fibrosis, methysergide was taken off the market.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Dangerous Substances Directive (67/548/EEC) Active ingredient Receptor antagonist Partialagonist Digital Object Identifier
566199
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