Michael N. Hall

Nip Michael Hall ( born June 12, 1953 in Puerto Rico ) is an American- Swiss molecular biologist and professor at the Biozentrum, University of Basel.

Life

Hall spent his childhood and youth in South America ( Venezuela, Peru ). He earned a bachelor's degree in 1976 in zoology at the University of North Carolina at Chapel Hill in 1981 and a PhD in Thomas J. Silhavy at Harvard University. His dissertation was entitled Genetic studies on the regulation of the major outer membrane porin proteins of Escherichia coli K- 12th Hall worked as a postdoctoral researcher at the Institut Pasteur in Paris and with Ira Herskowitz at the University of California, San Francisco. In 1987, Hall as Assistant Professor at the Biozentrum, University of Basel, 1992, he received a full professorship. From 1995 to 1998 and from 2002 to 2009, he headed the University's Department of Biochemistry, from 2002 to 2009 he was deputy director of the Biozentrum.

Work

1991 Hall discovered the protein kinase TOR. Hall is considered a leader in the exploration of the TOR signaling pathway ( mTOR in mammals ), which plays a crucial role in many processes of cell growth. Even with aging and obesity or various diseases such as cancer, diabetes mellitus or cardiovascular disease of the TOR signaling pathway is important. Substances that interfere here are considered to be potential therapeutic agents for various diseases.

Awards (selection)

Publications (selection )

• Heitman, J., N. R. Movva, and M. N. Hall. In 1991. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. In Science 253, 905-909.
• Schmelzle, T. and M. N. Hall. 2000th TOR, a central controller of cell growth. In Cell 103, 253-262.
• Lowith, R., E. Jacinto, S. Wullschleger, A. Lordan, JL Crespo, D. Bonenfant, W. Oppliger, P. Jenoe, and MN Hall. 2002nd Two TOR complexes, only one nominal real is rapamycin sensitive, have distinct roles in cell growth control. In Mol Cell 10, 457-468.
• Wullschleger, S., R. Lowith, and M. N. Hall. 2006th TOR signaling in growth and metabolism. In Cell 124, 471-484.
• Robitaille, AM, S. Christen, M. Shimobayashi, LL Fava, M. Cornu, S. Moes, C. Prescianotto - Baschong, U. Sauer, P. Jenoe, and MN Hall. 2013th Quantitative Phosphoproteomics reveal mTORC1 phosphorylates CAD and the activates de novo pyrimidine synthesis. In Science 339, 1320-1323.