Michael Sheetz
Michael Patrick Sheetz is a cell biologist at Columbia University. He pioneered mechanobiology and biomechanics.
Life
Sheetz earned a bachelor's degree in 1968 at Albion College in 1972 and a Ph.D. at the California Institute of Technology (Caltech ). As a postdoctoral fellow, he worked at the University of California, San Diego, before a first chair (1974 Assistant Professor, Associate Professor in 1980 ) in Physiology at the University of Connecticut in Farmington, Connecticut received. In 1985 he went as professor of cell biology and physiology at Washington University in St. Louis, Missouri. From 1990 to 2000, Sheetz professor ( "Professor and Chairman " ) of Cell Biology at Duke University Medical School in Durham, North Carolina. Since 1990 he is William R. Kenan, Jr. Professor of Cell Biology at Columbia University in New York City.
Work
Sheetz could make important contributions to understanding the mechanisms that are involved in the directed intracellular transport of macromolecules. This includes the operation of dynein and kinesin to microtubules. Sheetz ' work focuses on the one side with the mechanisms by which proteins act together like machines, on the other side with the biological processes in which these protein complexes are involved, including such diverse processes such as fertilization or brain function. Disorders of the kinesin structure could be associated with genetic diseases such as Charcot -Marie -Tooth.
Sheetz is concerned with the forces that cells can exercise and with what effect on the cellular metabolism and cellular behavior (eg, cell division ) have external forces.
Awards (selection)
- 2012 Wiley Prize in Biomedical Sciences
- 2012 Albert Lasker Award for Basic Medical Research
- 2013 Massry Prize