Molybdopterin

• MPT
• Pyranopterin dithiolato

Fixed

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Molydopterin is a chemical compound that builds on a Pterinring. Molydopterin together with a Molybdänion molybdenum cofactor ( MoCo ).

Properties

Molydopterin consists of a pyranopterin, a heterocycle of a pyran ring and a pteridine ring. At the pyran ring are two thiolates. In some cases, the Alkylphosphatgruppe is a Alkyldiphosphatnukleotidgruppe ( from adenosine diphosphate ).

Various enzymes use Molydopterin. Molydopterin is a cofactor of xanthine oxidase, the DMSO reductase, the sulphite, the nitrate, the Ethylbenzendehydrogenase, the glyceraldehyde -3-phosphate - ferredoxin oxidoreductase, the arsenate ( glutaredoxin ) and the carbon monoxide dehydrogenase. Furthermore, molybdopterin is a prosthetic group of various enzymes, such as the format dehydrogenase, purine hydroxylase and the thiosulfate reductase. Molybdopterin still occurs in the aldehyde oxidase.

In some bacterial species is bound up in their oxidoreductases on Molybdopterin instead of molybdate tungstate. These enzymes usually oxidize aldehydes to carboxylic acids. Some tungstate -binding oxidoreductases use selenium instead of sulfur.

Biosynthesis

Molybdopterin is synthesized from guanosine triphosphate. About a radical reaction with S- adenosylmethionine pyranopterin is formed in the first intermediate step. Then three more reaction steps, the formation of a Endithiolats. The phosphate group is coupled to adenosine diphosphate, which produced the molybdopterin.

The models of the active site of the molybdopterin -containing enzymes are derived from dithiols -containing ligands.