Murine leukemia virus

Murine leukemia virus or murine leukemia virus ( MLV, also MuLV ) is a virus of the genus Gamma retrovirus and belongs to the family of retroviruses. MLV belongs next to the human immunodeficiency virus and the avian leukosis virus to the most studied viral systems. There are many different strains of the virus that are named in part after their discoverers in part by the cells they infect. Most strains were, however, some isolated from mice also rats.

  • Graffi MLV (1955 )
  • Friend MLV (Fr -MLV ) ( 1957)
  • Moloney MLV (Mo -MLV or Mo -MuLV ) (1960 ), the first retrovirus whose genome was completely sequenced (1981). A human -infecting close relative of Mo -MLV, the Xenotropic Moloney murine leukemia virus -related virus ( XMRV ) was discovered in 2006.
  • Abelson MLV (Ab -MLV ) ( 1970)

These strains can be divided into four different groups, ecotropic, xenotropic, polytropic and amphotropic strains. For some tribes it is Endogenous retroviruses.

MLV is the virus most commonly used for the construction of retroviral vectors, and in many gene therapy studies in use. On the basis of MLV also replication competent vectors are being developed that will be used to combat tumors.

Species Dimer (chemistry) National Center for Biotechnology Information Ludwik Gross Arnold Graffi
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