N-Methylserotonin

  • 5-hydroxy- N- methyltryptamine
  • N?- Methyl serotonin
  • Nw -methyl-5 -hydroxytryptamine
  • Norbufotenin

Tryptamines

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5-hydroxy- N- methyltryptamine (abbreviated N-methyl serotonin), also Norbufotenin is an alkaloid from the family of tryptamine. It is a derivative of serotonin. The art is also the name N? Methyl serotonin, to distinguish it from tryptamine derivative compounds in which a methyl group to the nitrogen atom of the indole group is attached.

N- methyl serotonin is found in plants, animals and fungi, including Actaea racemosa ( Black Cohosh ), Zanthoxylum piperitum ( Sichuan pepper ), Litoria aurea ( gold tree frog ) and Amanita mushrooms ( Amanita ).

From the pharmacological point of view, N-methyl serotonin binding to several serotonin receptors, including the 5-HT1A and 5 -HT7 receptors with high affinity (IC50 ≤ 2 nM) and selectivity. In addition to the serotonergic activity of the compound also acts as a serotonin reuptake inhibitor.

CAS registry number PubChem Selective serotonin reuptake inhibitor Digital Object Identifier
589937
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